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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ada9b57410f22364b4fcec57c067e57e529543b9f00240e24671bd341df2d5a9' 
  AND token = 'H6k/BtgQoTg3cD4PMAzCNd55hHBbpfcgJ1tWO9Bznpo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}