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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221e994c4c142db6d62034aa2c98cb76bce39688393a98acdf6d4229ee1b80c8' 
  AND token = 'uxGIDyhljK5h/nZWSQJRRyPAUIcZbFKxlMscR5mXXOU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}