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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3df1e5a38c0e58a17bec1b6be062e4680cb8d115549bde8aca623592a06a3254' 
  AND token = '1Zu2WPTPNRicZo0OSB5wwyFZZ/VDzryagLfx8Z/jMvM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}