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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f4df4fd210ca5972d4ab187b21927b04a6d1cd6437421051daec395ce14a895' 
  AND token = 'LN8oK1TUskDUAjrMAd1JWHIAs9vJnv5//VW6E+sBCEM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}