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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50335861ba47b5d9aea6883815dfd13b2ac55f087b1d81dd27e229a5380ac81c' 
  AND token = 'DjbCRPdssiPVBo8zqQLaOwzTjoTd6d+6mSxi9sgBjrk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}