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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed4de122a86d4bdc9bb3e7138ed5c30678f144f90deb8f9844bed3f6fed35a16' 
  AND token = 'wcEQdmYhhR/xuReUwvrHtsC0nG2sP+MeGRr7Tn867cA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}