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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4dd828941717e1c861505c3037ab118cbaec1ff67cdf593680a1578252f40111' 
  AND token = 'GpPjmLlg+0jwI1rbIfzYQ3IQaCWjnOw3SLY9HrOD7vY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}