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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10ec19acf93f7a1b239668e2372ab5aee330e2bf906e915c017fba1f7bfd23e3' 
  AND token = 'TC6lzbPjI3irHdIxrRhd9yBpS4V4z+54nlWF3uJBpDo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}