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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ed21716edd0b7bd3e5ad004a25a0e9349aea34b21d1f5aab7b7fcc46422f47f' 
  AND token = 'jrxiAOLaOAnvUuII2fnVAuGPhwSUHrcRfhwTKbTpYvo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}