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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '100379b2f98892b4b86e3d012fd1b31967eb482d6ee161edf57da5af322ef6a3' 
  AND token = '2uI/CSIkyPdQLw80HcWz3QIkOCUQ/XH/B0Fj2GezBzA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}