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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '646108c47a39018eef4cd2eb027e9b7aa44b1c199c95f8ad6a3ed297b74fe65d' 
  AND token = 'fYxDhjEQU7JbovRlS3H3JaKQaP4O+RgAYrvXQ5SptEc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}