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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ea8de7651ea54033c16ebd3cbe36d0b5697f5745ecbdc745598d84fc75bc2458' 
  AND token = 'DFWO3CeuE4pZj1Krgc79oKhUEjNFNPBy6/kCpXc7KUw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}