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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '859f0eddfb0e6a7f5a936afd23cbde1b89fdb5598d2c0b1b02adb559a15e779a' 
  AND token = '9ZaWFHrv4LtCz1VILvKaZTxQvyeBZ/pocDxNkdo8tN8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}