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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '783191f41fcc2eaa1a5b8378d9792464f6c1e3e52bb94b01fd657aee7802e1a7' 
  AND token = 'KcKmN7OAL/QsQOzW+nDUHV1c/3DRG3TEy5/13RTmxqk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}