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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bdf1bbf33fda218090e9a42521ccc77489e935f6320f3f03b77cd6c0df16b21d' 
  AND token = 'bksjroRxHROGc/R281b4riakvU0XmJmbBozxcYxkAUE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}