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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '379144cd36a1746a7ef59b9bfc53a08d299caf8b53877c9d222fab67d6af5098' 
  AND token = 'CFy1mm0Xz1M4FWzyg2tX24p+dJ+A2dcfgo2ij/Dtsv0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}