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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53f8acf778cdf74ff911d7193fc8799f9e3fc4683331a2db067c2f904537217c' 
  AND token = '2KlP3PcjNy+ZEWs+L8IyzrjN3uMGvTGKjCL1NhNPXzk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}