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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41a20f4da0d7fcb68f20be2c448b2b2c5804cdca45fc111d39ee66d82acdc740' 
  AND token = 'A5yfLuiigPEBnSrBUpd+06GdGsv7+5sAcfMr4HfC+MI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}