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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a2206997893db0215b7f16f3dd28676157faf5942b7b138dfdc326946267c5c6' 
  AND token = 'P1fDfz43I16+ogy/cTDzCLyf+Wk6vSv3Mqx8+NBdwfw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}