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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b750d081b4570ecc524f2fe9c6fbac8a30151c28ce826a9b1f139e204e10c7fd' 
  AND token = 'xuIP8wMUFj8b3Juzuqx1zO+0hBvpzvnXv/84fSr8U8w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}