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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '77178d53366fb661be1029c45e26d5c9e71aa3c251dac4ad7fc6bd15b44c4720' 
  AND token = '2G50ARAK3H6dlGXW0irWkTLBhmYxeSBL+65P5gYfFQQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}