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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e9052809a9b56ee4198aceb53559d217c759555df78a23cab75a171b85f8e46d' 
  AND token = 'JV7PaYq6zGoNlbLKInmXqBOdqYw9qtpOhde1R3d7n5E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}