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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '563d3ccf8d379d5d06c84bfd420fd14b820903c4626b19228502e84a02dbe876' 
  AND token = 'cDownH4QDhKEd8KDqnydNJN3tQQ2z3YFcYcsXn3u8bg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}