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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59ad8809e7e0d3edabbc81dbde90d56ec77919736d63f9204eb3dca02e400ca0' 
  AND token = 'cdBoWTYnfSyFcxN3Di2nqej2r1ss0DO56FLvoRn4Y68=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}