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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9226463aa51a5a6fbf7f44988758ed0dc0676f2ca1edae75d585645ea13e6692' 
  AND token = 'tWFqxBcZ1vLeNb+ausjYxWE0gQ3GSGerlSbhikOa1Ac=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}