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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '180cb677af89fce3a6550dbcf1521c9b43ce85982e31c3b851e7c8dd9dc11f58' 
  AND token = 'x0cNHI3yOVjC/Mo/ptY+Z8mTWcIKqAVzUJJo9wiZtDI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}