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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f6a38b42808afbcf6adb35f06f44394aec7f2de81253d64103200034e9abfba' 
  AND token = 'sdBqAEszwA8UaXf6pKoN2mLJvqyVgHdT61Hwj1R36Zs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}