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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '421a0bf09add1c4dc9ad7d91e0eda5e694f29947fcfd3b5361837647d52f9515' 
  AND token = 'fz1nq8tNFF91LL0XVZW6o3WxM53PGYJbRzfCbWqmFxM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}