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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '121503a00fe4f4ce9c157404d5ce7a42392a3169d3f69b1cc40b95eb598d0e8a' 
  AND token = 'EP9fWKLdt6aQWZlD0wxUmZDPNbcH5KdwxxlIWs8QL2A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}