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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c2fdb9fe598ba9d4122788b00437377fb623421cf92e69e2b38812c4a396dfe' 
  AND token = 'JCsY3HU65Eu+HR8A+vRQHtCRPrtFW5ewV9UdIMquIb8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}