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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '459c625fd8041b8d243165cf5c2a68f32836a7375bd73559633fe9a9a4bd8925' 
  AND token = '9RntDT3dwzUNY5m0jBTWW79DqT7kJEb4i1E/KUpdUA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}