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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '487131f471e2f981043973861ad300110d11d5ae26d51af505554b2592155e25' 
  AND token = 'lOx9pgwTgN5TE7E/xNROoDzpgniHtF4hW3hPSqTaEEM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}