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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '578cbe8380293dc6f031009ff221da8d8b0903404e21f15d5984ec9fed8a68b1' 
  AND token = 'FOzO3NFxUmhygPLkZmz6uY5DAqNHMXts5i+oMqgqUqE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}