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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22e1066d5f0b7bba410aa0f11aacea5a327443e387f2a449badd23afe4b14c43' 
  AND token = '274ts9PG34Q7B+mKips+HP8vcR07zmGzwL2Zlgj6p4E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}