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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59e122df79b2754beffa01454246f227301b8139bfafa24fd1ee33dc8fa09d0b' 
  AND token = '9+tooGG8QbLrW+4XTs0a3YWJEUpCofb6nb8OjWV+FfQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}