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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ccbdd0bf73c15b14ac14e8092c0d29463ec8747bd78f6da6a71be75c3906821' 
  AND token = 'l+zV8HHqS0IF5T49b4t4E9ll4XtWpY3GFJZJxbrsbT4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}