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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fb49c97f70e46ed3a9b97a03776711dc78f69650f93d76d446d20e05f67831c9' 
  AND token = 'RDPRpdytsSba/6cC8erO+NQkS06snlS0sjMSeQabPOw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}