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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10e33b14231532348813a9011a3d499d0da9f3e86e1042a3419c0c5b4b70f2d8' 
  AND token = 'DtDptcaKmNRHYeDNvyYCRCrvq/5LYgWIoNYk89AlbCo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}