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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5181a3d46a357fd41e8c50a7b3ec077bbe55a41f4b2cb73259a9c991426cada9' 
  AND token = 'TpM60eByXRTAwvVCZweGCm8anHg7KFbhV1Wg60Z0JVo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}