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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd081fb330cd0ccac3285abb2f9d30d19cd94090d683897a51fb09f6bc8090583' 
  AND token = 'a7az8Rf6MftpE4hHD7wFiaGxzRlcE2dbkGv+nnyRBoI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}