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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '125efd3109eb0cb2bafb18e38e941486c98fd1dc79b05f8ad17705028be307cb' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}