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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f58c48ea3c727690e0584f54d5f2d2c1e945353625632d7be596938aab4ffa47' 
  AND token = 'CMz3L9/oKPM/nypjVffK8BR3AUkZ1Vf1TB0A5lk5BF4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}