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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721d72a6682d2bec9b330758e0fd715f35681fc4d22c5817abc249a1ed7d12bc' 
  AND token = 'TN1r3UmXxE17VpBqjhmVgRshH7dsTUAp5cR0XRKh3hI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}