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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a18597b95718fe829e5edfd5f226efc5f259e0df8b147019f9bfee9073bca82a' 
  AND token = 'uFAiD7DRGCSXY7FsRY3kmuqFh5NxaAT/MiM8+BRZMiM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}