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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '758728139ec0b02ba1d915e7211cd85c0d9fbb83c508948e544b02b8c78c64a1' 
  AND token = 'JA6c3tFVf60bFMO6sF7a5yOspu8MROHtk1FhImn9MSg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}