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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e3c4b4da5e18446f7d85020428d893cddf055fa5c82a1a1f67d240aa4aafb15' 
  AND token = 'A3/wS3uv1IWGDH+eSj+hUpNWpzxPPqaItRHhnXAn1b4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}