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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd12974f2d8a8d8306cd141ccd25e314fba5809270a4eabda3b8408a99aa74fdc' 
  AND token = 'Ed41PXgrEOWdj5KQKtI3mhu2t8LyHNOSxj0wUnTYsmA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}