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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e14f494c9dc266bb01f44d1561380401490ac5ab2affd418002a58c1c301a4be' 
  AND token = 'FFXlTe9aiXyuOlJrvOWGU/g1XbXpCHtndoi/047KBgI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}