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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cebc7842102915d84be89d4a53016b05b3cd279f9fd794e3c954ab116b12a42c' 
  AND token = 'PO6w/JgPcdYDAASWfhgoSAGYr7CY7fqhUmPSCbXT1dg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}