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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22c0d34c736fab826a8c03c0b0402df3a7c75ece791e8fa657708c4d8dda5421' 
  AND token = 'r6OHtjZxPnOo9npBKSiSXwEk2a8z5meW7FcQLuZ3TE4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}